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SASInstitute A00-282 Exam Syllabus Topics:
| Section | Weight | Objectives |
|---|---|---|
| Manage Clinical Trials Data | 5% | - Clean, merge, and subset data - Access and explore clinical datasets - Use SQL and dictionary tables |
| Regulatory Submissions | 5% | - ICH and FDA guidelines - Compliance for clinical data reporting |
| Report Clinical Trials Results | 10% | - PROC REPORT and PROC PRINT - Produce tables, listings, and figures |
| Macro Programming for Clinical Trials | 15% | - Macro variables and parameters - Debugging macros - Create and call macros |
| Apply Statistical Procedures for Clinical Trials | 15% | - Basic statistical analysis for clinical data - PROC MEANS, FREQ, TABULATE |
| Transform or Summarize Clinical Trials Data | 15% | - Data step manipulation - Derive variables and study days - Aggregation and transposition |
| Clinical Trials Process | 5% | - Clinical trial lifecycle and protocol - Derive programming requirements from protocol and CRF |
| Clinical Trials Data Structures | 10% | - Clinical domain structures - CDISC standards: SDTM, ADaM - Define.xml and dataset specifications |
| Validate Clinical Trial Data Reporting | 20% | - Validation principles - Programming validation techniques - Use PROC COMPARE and log review |
SASInstitute Clinical Trials Programming Using SAS 9.4 Sample Questions:
1. Given the following data set DEMOG:
Which selection below would be considered hard-coding?
A) birthdt = input(dob, mmddyy10.);
B) if site eq 1 and sexcd ne 2 then check = 1; else if site eq 2 and sexcd ne 1 then check = 2;
C) if sexcd eq 1 then sex = "Male"; else if sexcd eq 2 then sex = "Female";
D) if site eq 1 then sexcd = 2; else if site eq 2 then sexcd = 1;
2. Given the following SCORE data set:
Based on the concept of Last Observation Carried Forward, what will be the value for SCORE for the Week 12 -
A) 152
B) missing
C) 157
D) 153
3. By default, the PROC FREQ in the code below produces an output object named CrossTabFreqs and the PROC MEANS produces an output object named Summary.
<insert code here>
proc freq data = Work.AE;
table USUBJID*AEPTCD;
run;
proc means data = work.LB max;
class USUBJID;
var STUDYDY;
run;
Which code segment can be added prior to the PROC FREQ step to ensure that PROC MEANS produces its output object but PROC FREQ produces no output object?
A) ODS EXCLUDE CrossTabFreqs;
B) ODS SELECT NONE:
C) ODS EXCLUDE ALL;
D) ODS SELECT Summary;
4. A Statistical Analysis Plan (SAP) defines the selection process for baseline records. This instructs the programmer to choose the last non-missing analyte value prior to first study drug administration (date/time).
The DEMO data set contains the date/time of first study drug administration for subject:
What will be the resulting baseline values, as selected per the SAP instructions?
A) Option A
B) Option C
C) Option B
D) Option D
5. Which SAS program will apply the data set label 'Demographics' to the data set named DEMO?
A) data demo (label='Demographics');
set demo;
run;
B) data demo (label 'Demographics');
set demo;
run;
C) data demo;
set demo (label='Demographics');
run;
D) data demo; set demo;
label demo= 'Demographics';
run;
Solutions:
| Question # 1 Answer: B | Question # 2 Answer: C | Question # 3 Answer: A | Question # 4 Answer: D | Question # 5 Answer: A |







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